Delphine Casabonne


Delphine Casabonne

Delphine Casabonne holds a degree in Mathematics (Pau, France, 1998), a Master in Statistics (University College London, UK, 1999), and a PhD in Cancer Epidemiology on the seroepidemiology of human-papillomavirus in relation to non-melanoma skin cancer (University of London-QMUL, UK, 2009).

From 1999 to 2009 she worked at the Cancer Epidemiology Unit at the Oxford University (CRUK, previously ICRF) as a medical statistician mainly focusing on the association between infections and cancers using data from case-control studies in Uganda and Malawi as well as working on cancer risk factors in large cohort studies (EPIC and the Million Women Study).

In 2009 she joined the haematological malignancy research group at the Cancer Epidemiology Research Program (PREC) of the Catalan Institute of Oncology (ICO/IDIBELL) as a postdoc under CIBERESP. Her research is centered on the use of epidemiological approaches to study risk factors associated with the aetiology of haematological cancers with a particular interest in B-cell precursor stages. She aims to get a better understanding of the interactions between infectious agents and the immune system and to identify the factors involved in the progression from early precursor stages to cancer and cancer survival. Since 2016, she is responsable of the haematological malignancy research group at PREC.

Dr Casabonne leads new efforts to develop cohort and case-control studies on B-cell precursors to identify the environmental, lifestyle, infectious, genetic and biological factors (IBERISAL and IBERICAT studies) associated with these conditions and the progression to cancer aiming to identify preventive measures. This work is done in collaboration with the Salamanca Cancer Research Center (CIC), the ICO centers and the Hospital de Sant Joan Despí Moisès Broggi. Dr Casabonne collaborates in different epidemiological studies and consortium: the Spanish Multicase-Control Study (MCC-Spain) on chronic lymphocytic leukemia analyzing the influence of environmental factors and their interaction with genetic factors in five cancers; the evaluation of the environmental and occupational exposures associated to lymphoma risk as part of the European Study of Lymphomas (EpiLymph); the GenRisk Network, which compiles and analyzes genetic biomarkers as cancer risk factors in order to shape future prevention strategies; the consortia INTERLYMPH and CRUCIAL, to examine environmental and genetic factors associated with different haematological cancers; the lymphoma and leukemia working group of the EPIC study to examine prospectively risk factors as well as biomarkers associated with subsequent haematological cancers; as well as other projects in collaboration with ISglobal (infection acquisition in early life and health outcomes and COVID-19 studies).



Saberi Hosnijeh F, Casabonne D, Nieters A, et al. Association between anthropometry and lifestyle factors and risk of B-cell lymphoma: An exposome-wide analysis. Int J Cancer. 2020. doi: 10.1002/ijc.33369

Casabonne D, Benavente Y, Seifert J, et al. Serum levels of hsa-miR-16-5p, hsa-miR-29a-3p, hsa-miR-150-5p, hsa-miR-155-5p and hsa-miR-223-3p and subsequent risk of chronic lymphocytic leukemia in the EPIC study. Int J Cancer. 2020;147(5):1315-1324. doi: 10.1002/ijc.32894

Benavente Y, Costas L, Rodríguez-Suarez MM, […], Casabonne D. Occupational Exposure to Pesticides and Chronic Lymphocytic Leukaemia in the MCC-Spain Study. Int J Environ Res Public Health. 2020;17(14):5174. doi: 10.3390/ijerph17145174

Solans M, Benavente Y, Saez M, [...],Casabonne D. Inflammatory potential of diet and risk of lymphoma in the European Prospective Investigation into Cancer and Nutrition. Eur J Nutr. 2019 Mar 22. doi: 10.1007/s00394-019-01947-0

Saberi Hosnijeh F, Kolijn PM, Casabonne D, et al. Mediating effect of soluble B-cell activation immune markers on the association between anthropometric and lifestyle factors and lymphoma development. Sci Rep. 2020;10(1):13814. doi: 10.1038/s41598-020-70790-9

Solans M, Benavente Y, Saez M, [...] Casabonne D. Adherence to the Mediterranean diet and lymphoma risk in the European Prospective Investigation into Cancer and Nutrition. Int J Cancer. 2019 Jul 1;145(1):122-131. doi: 10.1002/ijc.32091

Flores JC, Gracia-Lavedan E, Benavente Y, [...], Casabonne D. The Dietary Inflammatory Index and Chronic Lymphocytic Leukaemia in the MCC Spain Study. Nutrients. 2019;12(1):48. doi: 10.3390/nu12010048

Costas L, Lujan-Barroso L, Benavente Y, [...], Casabonne D. Reproductive factors, exogenous hormone use and risk of B-cell non-Hodgkin lymphoma in a cohort of women from the European Prospective Investigation into Cancer and Nutrition. Am J Epidemiol. 2019 Feb 1;188(2):274-281. doi: 10.1093/aje/kwy259

Casabonne D, Benavente Y, Costas L, et al. Insulin-like growth factor levels and chronic lymphocytic leukaemia: results from the MCC-Spain and EpiLymph-Spain studies. Br J Haematol. 2018 Nov 19. doi: 10.1111/bjh.15583

Solans M, Castelló A, Benavente Y, [...], Pollán M*, Casabonne D*. Adherence to the Western, Prudent, and Mediterranean dietary patterns and chronic lymphocytic leukemia in the MCC-Spain study. Haematologica. 2018;103(11):1881-1888. doi: 10.3324/haematol.2018.192526
(*co-senior authorship)