Sònia Paytubi Casabona

Researcher

Sònia Paytubi Casabona

Sònia Paytubi holds a Biology degree (1998) and a PhD in Microbiology (2004) from the University of Barcelona (UB), where she specialized in gene expression regulation in enteric bacteria. Following her PhD, she completed two postdoctoral stages at the Universities of Dundee and St Andrews (Scotland, UK), working on translational and transcriptional regulation in eukaryotes and Archaea. After returning to the University of Barcelona in 2009, she combined research on bacterial gene regulation with undergraduate and postgraduate teaching and the supervision of BSc, MSc and PhD students.

In 2018, she joined the Infection and Cancer Laboratory (INCALAB) at the Cancer Epidemiology Research Programme of the Catalan Institute of Oncology (ICO-IDIBELL), where she redirected her research towards cancer prevention, HPV-related diseases and molecular epidemiology. During her first year at ICO, she coordinated a Phase III clinical trial evaluating the immunogenicity and tolerability of the 9-valent HPV vaccine (GARDASIL®9) in adult women.

Her current research focuses on the development and validation of molecular biomarkers and minimally invasive diagnostic approaches for the early detection of HPV-related anal cancer and gynaecological cancers. She led the ELAVImet project, which investigated novel viral and host biomarkers for the detection of anal high-grade squamous intraepithelial lesions among GBMSM living with HIV. Through the aSELF-GEN project, she evaluated the feasibility and diagnostic performance of anal self-sampling for HPV detection in GBMSM and transgender women (TGW), contributing to the development of more accessible screening strategies. She is currently co-Principal Investigator of the GAIA study, which explores anal cancer risk and prevention strategies in women with HPV-related genital neoplasia, an understudied population in anal cancer research. In parallel, she has contributed to the SCREENWIDE and GAIN-EC projects, focused on the identification and validation of genomic biomarkers in minimally invasive samples, including urine and cervicovaginal specimens, for the early detection of endometrial cancer. Her work combines molecular biology, next-generation sequencing and epidemiological approaches to develop innovative and accessible screening strategies based on self-sampling and minimally invasive specimens.

She is an active member of CIBERESPand collaborates extensively with national and international research groups in HPV epidemiology, cancer prevention and translational oncology.

Beyond research, she is actively involved in science communication and cancer prevention initiatives. She contributes to the coordination of Mejor Sin Cáncer, an evidence-based outreach platform led by researchers from ICO and IDIBELL that promotes cancer prevention and public awareness.

ORCID: orcid.org/0000-0002-5392-953X
Email: spaytubic@iconcologia.net


SELECTED PUBLICATIONS:

Costas L, Frias-Gomez J, Guardiola M +(…)+ Paytubi S, et al. “New perspectives on screening and early detection of endometrial cancer”. Int J Cancer 2019; 145(12):3194-3206. doi: 10.1002/ijc.32514

Paytubi S, Casado C, Madrid C, et al. “Nutrient composition promotes switching between pellicle and bottom biofilm in Salmonella”. Frontiers in Microbiology 2017; 8:2160. doi: 10.3389/fmicb.2017.02160

Paytubi S, de La Cruz M, Tormo JR, et al. “A High-Throughput Screening Platform of Microbial Natural Products for the Discovery of Molecules with Antibiofilm Properties against Salmonella”. Frontiers in Microbiology 2017; 8: 1-13. doi: 10.3389/fmicb.2017.00326

Gibert M, Paytubi S*, Beltrán S, et al. “Growth phase-dependent control of R27 conjugation is mediated by the interplay between the plasmid-encoded regulatory circuit TrhR/TrhY-HtdA and the cAMP regulon”. Environ Microbiol 2016; 18:5277-5287. doi: 10.1111/1462-2920.13579
*co-first author

Solórzano C, Srikumar S, Canals R +(…)+ Paytubi S*, Madrid C. “Hha has a defined regulatory role that is not dependent upon H-NS or StpA”. Frontiers in Microbiology 2015; 30:773. doi: 10.3389/fmicb.2015.00773
*co-senior author

Hüttener M, Paytubi S*, Juárez A. 2015. “Success incorporating horizontally transferred genes: the H-NS protein”. Trends in Microbiol 2015, 23:67-69. doi: 10.1016/j.tim.2014.12.009
*co-first author

Paytubi S, Aznar S, Madrid C, Balsalobre C, Dillon SC, Dorman CJ, Juárez A. “A novel role for antibiotic resistance plasmids in facilitating Salmonella adaptation to non-host environments”. Environ Microbiol 2014; 16:950-962. doi: 10.1111/1462-2920.12244

Paytubi S* McMahon SA, Graham S, Liu H, Botting CH, Makarova KS, Koonin EV, Naismith JH, White MF. “Displacement of the canonical single-stranded DNA-binding protein in the Thermoproteales”. Proc Natl Acad Sci U S A 2012; 109:E398-405. doi: 10.1073/pnas.1113277108
*co-first author

Paytubi S, White MF. “The crenarchaeal DNA damage inducible transcription factor B paralogue TFB3 is a general activator of transcription”. Molecular Microbiology 2009; 72: 1487-1499. doi: 10.1111/j.1365-2958.2009.06737.x

Paytubi S, Wang X, Lam YW, Izquierdo L, Hunter MJ, Jan E, Hundal HS, Proud CG. “ABC50 promotes translation initiation in mammalian cells”. J Biol Chem 2009; 284:24061-24073. doi: 10.1074/jbc.M109.031625